Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)
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چکیده
منابع مشابه
A potential anticancer agent: 5-chloro-7-iodo-8-hydroxyquinolinium dichlorido(5-chloro-7-iodoquinolin-8-olato-κ2 N,O)palladium(II) dihydrate
The title Pd(II) coordination compound, (C(9)H(6)ClINO)[PdCl(2)(C(9)H(4)ClINO)]·2H(2)O, was prepared as a potential anti-cancer agent. Its structure is ionic and consists of a square-planar [PdCl(2)(CQ)](-) complex anion (CQ is 5-chloro-7-iodo-quinolin-8-olate), with the Pd(II) atom surrounded by two chloride ligands in a cis configuration and one N,O-bidentate CQ mol-ecule, a protonated anion ...
متن کاملEffect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose
8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8...
متن کامل5-Chloro-8-hydroxyquinolinium nitrate
The 5-chloro-8-hydroxy-quinolinium cation in the the title ion pair, C(9)H(7)ClNO(+)·NO(3) (-), is approximately coplanar with the nitrate anion [dihedral angle = 16.1 (1)°]. Two ion pairs are hydrogen bonded (2 × O-H⋯O and 2 × N-H⋯O) about a center of inversion, generating an R(4) (4)(14) ring.
متن کاملDesign, synthesis and anti-HIV integrase evaluation of N-(5-chloro-8-hydroxy-2-styrylquinolin-7-yl)benzenesulfonamide derivatives.
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.
متن کاملX-ray Charge-Dens Study of 5-Chloro-8-hydroxy-6-methyloaphthalene-l.4-dione: A Hydroxynaphthoquinone Derivative
The X-ray charge density analysis of a hydroxynaphthoquinnne derivative was obtained by multipolar Hansen-Coppens formalism refinement through high resolution X-ray diffraction data at 100(1) K. The molecularproperties of the title compound resulted from the combined experimental and the quantum theory of atoms inmolecules (QTAIM) studies. The topological properties of the covalent bonds and of...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2011
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2011.06.032